Histopathological Comparative Analysis between Syndromic and Non-Syndromic Odontogenic Keratocysts: A Retrospective Study

(1) Background: The aim of this study was to compare the histopathological features syndromic and non-syndromic odontogenic keratocysts (OKs) using conventional Confocal Laser Scanning Microscopy (CLSM) with their biological behaviour. (2) Methods: Data from medical records 113 patients histological diagnosis (single and/or multiple) OKs were collected. Globally, 213 (120 93 sporadic) retrieved, slides re-evaluated H&E staining autofluorescence on same CLSM (Nikon Eclipse E600 microscope). (3) Results: Syndromic showed more satellite cysts than sporadic cases, as well a basophilic layer in basement membrane, which absent OKs; both highlighted CLSM. membrane appeared amorphous fragile, thus possibly being responsible for epithelial detachment collapse, scalloped features. Furthermore, basal layers such cases also increased cellularity proliferative activity. All these may justify higher tendency recur. (4) Conclusions: is useful advanced technology that could help quickly easily discriminate between accurately predict behaviour order set fitter clinico-radiological follow-ups individual patients.